Provider-supervised catalog
Sleep-support treatments use prescription medications such as low-dose doxepin and trazodone that a clinician may consider for sleep. Every option lists its exact strength and price, and is prescribed only after an independent, licensed U.S. provider reviews your intake.
3 treatments
Doxepin 1–10 mg Capsules
Low-dose doxepin quiets the brain's wake-promoting histamine signal. A non-controlled option for people who struggle to stay asleep.
5 strengths available
from $31.00
Choose options
Doxepin 1–6 mg Gummies
Low-dose doxepin in a gummy format for people who struggle to stay asleep. Same provider-directed care, no capsules required.
4 strengths available
from $45.99
Choose options
Trazodone 12.5–150 mg Tablets
A widely prescribed, non-controlled medication used off-label for sleep. Works on serotonin signaling tied to arousal and wakefulness.
6 strengths available
from $32.00
Choose optionsHow prescription sleep medications work: the main pathways
A plain-language look at the signaling systems behind the sleep-wake cycle and how the main classes of prescription sleep medication are understood to act on them.
How trazodone and low-dose doxepin are understood to be used off-label for sleep
A neutral, mechanism-focused look at two prescription medications that originated as antidepressants and are discussed off-label in sleep contexts.
What sleep architecture is: REM, deep sleep, and the sleep cycle explained
A plain-language look at how a night of sleep is structured — the NREM stages, REM, the repeating sleep cycle, and the homeostatic and circadian drives that shape when we sleep.
Histamine and sleep: why H1 receptor antagonism is associated with drowsiness
A plain-language look at the brain's histamine system, the H1 receptor involved in wakefulness, and why reducing signaling at that receptor is understood to be associated with drowsiness — the pathway relevant to low-dose doxepin.
How melatonin signals day and night: the pineal hormone of darkness
A neutral, mechanism-focused look at how the pineal gland turns serotonin into melatonin at night and how MT1 and MT2 receptors read that signal as darkness and time of day.
How light sets the body clock: the suprachiasmatic nucleus and melanopsin
A plain-language look at how the brain's master clock keeps roughly 24-hour time and how melanopsin-containing cells in the eye tie that clock to the daily cycle of light and dark.
Adenosine and sleep pressure: the science of the homeostatic sleep drive
A plain-language look at how adenosine builds up during the hours you are awake to create homeostatic sleep pressure, and why caffeine's blockade of adenosine receptors is associated with alertness.
How GABA calms the nervous system: the brain's main inhibitory signal
A neutral, mechanism-focused look at gamma-aminobutyric acid — the central nervous system's primary inhibitory signal — and the two receptor families that carry it.
Orexin and the brain's wake switch: the hypocretin wake-promoting system
A plain-language look at the hypothalamic orexin (hypocretin) neurons that stabilize being awake, and the flip-flop switch model that keeps sleep-wake transitions sharp.
